Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fadrozole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 15/20 | 1.00 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.97 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fadrozole SCHEMBL122801 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Dexfadrostat SCHEMBL4619633 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Fadrozole SCHEMBL4143 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Dexfadrostat SCHEMBL685516 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| S-Fadrozole SCHEMBL13449014 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Fadrozole SCHEMBL25491 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Fadrozole SCHEMBL3295820 | 0.99 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Fadrozole SCHEMBL1650121 | 0.96 | CYP19A1 (0.95) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| SCHEMBL2351202 | 0.95 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 | |
| Hydrochloric Acid SCHEMBL9836543 | 0.92 | CYP19A1 (1.00) | CYP19A1CYP11B2CYP11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098911-A | Enzyme inhibitors and antiestrogens, storage stability | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | claimed |
| WO-2025068686-A1 | TREATMENT FOR BATTEN DISEASE | THE ROYAL VETERINARY COLLEGE (GB) | 2025-04-03 | — | — | WO | disclosed |
| WO-2024241997-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER | ＩＳＭ株式会社 | 2024-11-28 | — | — | WO | disclosed |
| WO-2022211075-A1 | METHOD FOR MANUFACTURING ANTIBODY-DRUG CONJUGATE AND ENZYME USED FOR SAME | 日本マイクロバイオファーマ株式会社 | 2022-10-06 | — | — | WO | disclosed |
| US-5098911-A | Enzyme inhibitors and antiestrogens, storage stability | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | disclosed |