Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | GLA | P06280 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740515 | 0.89 | PSEN1 (0.42) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8811316 | 0.88 | BACE1 (0.35) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8811078 | 0.84 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8809490 | 0.83 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8809156 | 0.82 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8808862 | 0.82 | KMT2A (0.45) | KDM4EALDH1A1HRH3 | |
| SCHEMBL8809060 | 0.81 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8809445 | 0.78 | BACE1 (0.35) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8807376 | 0.76 | PSEN1 (0.40) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8809275 | 0.73 | PSEN1 (0.36) | PDE4APDE4BPDE4CPDE4DPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096914-A | Hypotensive agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1992-03-17 | — | — | US | disclosed |
| US-5028711-A | Hypotensive Agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1991-07-02 | — | — | US | disclosed |