⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309777 | 0.82 | — | — | |
| SCHEMBL3276233 | 0.77 | — | — | |
| SCHEMBL8765 | 0.75 | — | — | |
| SCHEMBL523901 | 0.75 | — | — | |
| SCHEMBL16689107 | 0.73 | TTR (0.33) | — | |
| SCHEMBL4381778 | 0.73 | GLA (0.44) | — | |
| SCHEMBL4492568 | 0.73 | DAO (0.37) | — | |
| Hydrogen Sulfide SCHEMBL17843421 | 0.71 | GBA1 (0.31) | — | |
| SCHEMBL1966442 | 0.71 | KDM4E (0.40) | — | |
| SCHEMBL16118878 | 0.71 | TNKS2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217764-A1 | NOX INHIBITORS FOR USE IN THE TREATMENT OF ALPORT SYNDROME | CALLIDITAS THERAPEUTICS SUISSE SA (CH) | 2023-11-16 | — | — | WO | claimed |
| CN-111606887-B | Novel kinase inhibitor | 安徽中科拓苒药物科学研究有限公司 | 2023-03-17 | — | — | CN | claimed |
| EP-4023643-A1 | PYRAZOLE DERIVATIVE AND USE THEREOF | Hefei Institutes of Physical Science, Chinese Academy of Sciences (CN) | 2022-07-06 | — | — | EP | claimed |
| US-20220143001-A1 | NOVEL PAN-RAF KINASE INHIBITOR AND USE THEREOF | Tarapeutics Science Inc. (CN) | 2022-05-12 | — | — | US | claimed |
| CN-108137513-B | Pyrimidine derivatives | ASKA 制药株式会社 | 2022-03-01 | — | — | CN | claimed |
| EP-3932913-A1 | NEW-TYPE PAN-RAF KINASE INHIBITOR AND USE THEREOF | Tarapeutics Science Inc. (CN) | 2022-01-05 | — | — | EP | claimed |
| CN-112442014-B | PDGFR kinase inhibitors and uses thereof | 中国科学院合肥物质科学研究院 | 2021-10-08 | — | — | CN | claimed |
| US-20210177811-A1 | USE OF NOX INHIBITORS FOR TREATMENT OF CANCER | CALLIDITAS THERAPEUTICS SUISSE SA (CH) | 2021-06-17 | — | — | US | claimed |
| CN-112442014-A | PDGFR kinase inhibitors and uses thereof | 中国科学院合肥物质科学研究院 | 2021-03-05 | — | — | CN | claimed |
| WO-2021035788-A1 | PYRAZOLE DERIVATIVE AND USE THEREOF | 中国科学院合肥物质科学研究院 | 2021-03-04 | — | — | WO | claimed |
| US-7019012-B2 | Tyrosine inhibitors; antitumor agents; respiratory system disorders | BOEHRINGER INGELHEIM INTERNATIONAL PHARMA GMBH & CO. KG (DE) | 2006-03-28 | — | — | US | claimed |
| EP-1630165-A1 | [1,2,4 ]TRIAZOLO [1,5-A]PYRIMIDIN-2-YLUREA DERIVATIVE AND USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2006-03-01 | — | — | EP | claimed |
| US-20050159436-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-07-21 | — | — | US | claimed |
| US-20050107358-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-05-19 | — | — | US | claimed |
| US-20040044014-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | US | claimed |
| US-6627634-B2 | Antitumor agents, treatment of the lungs and respiratory tract | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-09-30 | — | — | US | claimed |
| US-20020173509-A1 | Quinazoline derivatives and phamaceutical compositions containing them | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-11-21 | — | — | US | claimed |
| US-20010044435-A1 | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2001-11-22 | — | — | US | claimed |
| US-4413001-A | ANTIDEPRESSANTS | DELALANDE S.A. (FR) | 1983-11-01 | — | — | US | claimed |
| US-4348393-A | ANTIDEPRESSANTS | DELALANDE S.A. (FR) | 1982-09-07 | — | — | US | claimed |