Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 8/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.52 |
| ▸ | EED | O75530 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | HLA-A | P04439 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9740909 | 0.86 | SSTR5 (0.59) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL11485803 | 0.86 | SSTR5 (0.78) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL10428946 | 0.86 | SSTR5 (0.57) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL9630095 | 0.83 | SSTR5 (0.72) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL10551207 | 0.83 | SSTR5 (0.58) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL9698198 | 0.83 | SSTR5 (0.55) | SSTR5KCNH2NR4A2EEDHRH1 | |
| Bromide SCHEMBL9699462 | 0.81 | KCNH2 (0.72) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL9631552 | 0.81 | SSTR5 (0.72) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL1151559 | 0.80 | KCNH2 (0.78) | SSTR5KCNH2NR4A2EEDHRH1 | |
| SCHEMBL9698218 | 0.78 | GAA (0.55) | SSTR5KCNH2NR4A2EEDHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126339-A | Antihistamine, antiserotonine | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-30 | — | — | US | disclosed |
| US-5025014-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-06-18 | — | — | US | disclosed |
| US-4888426-A | CHEMICAL INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-12-19 | — | — | US | disclosed |
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| US-4695569-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| US-4634704-A | HISTAMINE AND SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-01-06 | — | — | US | disclosed |
| EP-0145037-A2 | N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |
| EP-0144101-A2 | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-12 | — | — | EP | disclosed |