Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 2/20 | 0.38 |
| ▸ | LDHB | P07195 | 2/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739756 | 0.87 | PRKCI (0.56) | PRKCIPTPN1PTPN11CA12MEN1 | |
| SCHEMBL9739521 | 0.87 | PRKCI (0.56) | PRKCIPTPN1PTPN11CA12MEN1 | |
| SCHEMBL11116296 | 0.85 | PRKCI (0.50) | PRKCICA12MEN1KMT2ACYP3A4 | |
| SCHEMBL9740854 | 0.79 | PRKCI (0.51) | PRKCIPTPN1PTPN11CA12MEN1 | |
| SCHEMBL9739914 | 0.79 | PRKCI (1.00) | PRKCIPTPN1PTPN11CA12THRB | |
| SCHEMBL11106815 | 0.77 | PRKCI (0.46) | PRKCIPTPN1PTPN11CA12MEN1 | |
| SCHEMBL19422407 | 0.75 | PTPN1 (0.74) | PRKCIPTPN1PTPN11CA12MEN1 | |
| SCHEMBL9376210 | 0.75 | PTPN1 (0.50) | PRKCIPTPN1PTPN11MEN1KMT2A | |
| SCHEMBL10690373 | 0.73 | MEN1 (0.53) | PRKCIMEN1KMT2A | |
| SCHEMBL23399911 | 0.73 | PRKCI (0.62) | PRKCIPTPN1PTPN11CA12LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0104018-A2 | Benzopyran, benzothiapyran and quinoline compounds and pharmaceutical compositions containing them | FISONS plc (GB) | 1984-03-28 | — | — | EP | disclosed |