Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 12/20 | 0.76 |
| ▸ | CACNA1F | O60840 | 11/20 | 0.76 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.76 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9744750 | 1.00 | CACNA1C (0.76) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9744562 | 0.93 | CACNA1C (0.73) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9744567 | 0.93 | CACNA1C (0.73) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL10570131 | 0.90 | CACNA1C (0.61) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL10570124 | 0.90 | CACNA1C (0.61) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9744685 | 0.90 | CACNA1C (0.67) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9744679 | 0.90 | CACNA1C (0.67) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7275991 | 0.88 | CACNA1F (0.82) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL10746695 | 0.88 | CACNA1B (0.89) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL10746692 | 0.88 | CACNA1B (0.89) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215250-B1 | 2-SUBSTITUTED-1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-30 | — | — | EP | claimed |
| US-4845113-A | USEFUL IN RADICAL SCAVENGING THERAPY | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-04 | — | — | US | claimed |
| EP-0215250-A1 | 2-Substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-25 | — | — | EP | claimed |
| EP-0215250-B1 | 2-SUBSTITUTED-1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-30 | — | — | EP | disclosed |
| US-4845113-A | USEFUL IN RADICAL SCAVENGING THERAPY | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-04 | — | — | US | disclosed |
| EP-0215250-A1 | 2-Substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-25 | — | — | EP | disclosed |