SCHEMBL9744737

SCHEMBL9744737

CCOC(=O)C1=CN(C=Cc2ccccc2)C(C)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 11/20 0.56
CACNA1F O60840 10/20 0.56
CACNA1D Q01668 10/20 0.56
CACNA1S Q13698 10/20 0.56
ADORA3 P0DMS8 2/20 0.56
CYP1A2 P05177 3/20 0.55
CYP3A4 P08684 3/20 0.55
CYP2C9 P11712 3/20 0.55
CYP2C19 P33261 3/20 0.55
MAPT P10636 3/20 0.55
CYP2D6 P10635 2/20 0.55
TSHR P16473 2/20 0.55
NFKB1 P19838 2/20 0.55
LMNA P02545 2/20 0.55
GMNN O75496 1/20 0.55
BLM P54132 1/20 0.55
PMP22 Q01453 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
CACNA1B Q00975 2/20 0.54
HIF1A Q16665 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10515946 0.83 CYP1A2 (0.62) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL9874156 0.82 CACNA1F (0.63) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10694133 0.81 CACNA1F (0.62) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10653186 0.78 CACNA1F (0.73) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10472338 0.77 PDE4B (0.66) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11685999 0.77 CACNA1F (0.65) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL3443984 0.77 CACNA1F (0.67) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11688007 0.77 MAPT (0.70) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11688202 0.77 CYP1A2 (0.70) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL3443991 0.77 CACNA1F (0.67) CACNA1CCACNA1FCACNA1DCACNA1SADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215250-B1 2-SUBSTITUTED-1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-12-30 EP disclosed
US-4845113-A USEFUL IN RADICAL SCAVENGING THERAPY BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) 1989-07-04 US disclosed
EP-0215250-A1 2-Substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1987-03-25 EP disclosed