Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 10/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.70 |
| ▸ | AURKA | O14965 | 7/20 | 0.70 |
| ▸ | KDR | P35968 | 6/20 | 0.70 |
| ▸ | LCK | P06239 | 4/20 | 0.70 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.65 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974394 | 0.89 | TEK (0.80) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL976060 | 0.89 | TEK (0.79) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL974780 | 0.88 | TEK (0.79) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL2904459 | 0.88 | TEK (0.79) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL973651 | 0.88 | TEK (0.79) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL973869 | 0.88 | TEK (0.79) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL974466 | 0.87 | TEK (1.00) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL973066 | 0.87 | TEK (0.77) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL972826 | 0.87 | TEK (0.77) | TEKAURKBAURKAKDRLCK | |
| SCHEMBL973907 | 0.87 | TEK (0.77) | TEKAURKBAURKAKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |