Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.45 |
| ▸ | HMGCR | P04035 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 5/20 | 0.44 |
| ▸ | CES1 | P23141 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARD | Q03181 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10607844 | 0.98 | KMT2A (0.54) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL2452930 | 0.93 | KMT2A (0.59) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL9421864 | 0.93 | KMT2A (0.59) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL27371777 | 0.93 | KMT2A (0.59) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL1019921 | 0.93 | KMT2A (0.59) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL19547103 | 0.93 | MAPT (0.46) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL8496725 | 0.91 | KMT2A (0.45) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL8060807 | 0.89 | KMT2A (0.48) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL27703598 | 0.86 | KMT2A (0.56) | KMT2AMAPTPTPN7HMGCRCES2 | |
| SCHEMBL11577506 | 0.84 | KMT2A (0.59) | KMT2AMAPTPTPN7HMGCRCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162764-A1 | Composition and method for enhancing absorption of drugs from gastrointestinal tract using acylcarnitines | MERCK & CO. INC. (US) | 1985-11-27 | — | — | EP | claimed |
| EP-0214898-B1 | CHOLINE ESTERS AS ABSORPTION-ENHANCING AGENTS FOR DRUG DELIVERY THROUGH MUCOUS MEMBRANES OF THE NASAL, BUCCAL, SUBLINGUAL AND VAGINAL CAVITIES | MERCK & CO. INC. (US) | 1992-03-11 | — | — | EP | disclosed |
| US-4973579-A | VIRICIDES | MERCK & CO., INC. (US) | 1990-11-27 | — | — | US | disclosed |
| US-4963556-A | ANTIVIRAL AGENTS | MERCK & CO., INC. (US) | 1990-10-16 | — | — | US | disclosed |
| EP-0162764-B1 | COMPOSITION AND METHOD FOR ENHANCING ABSORPTION OF DRUGS FROM GASTROINTESTINAL TRACT USING ACYLCARNITINES | MERCK & CO. INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| US-4835138-A | Choline esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities | MERCK & CO., INC. (US) | 1989-05-30 | — | — | US | disclosed |
| US-4822773-A | Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts | MERCK & CO., INC. (US) | 1989-04-18 | — | — | US | disclosed |
| US-4729989-A | Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts | MERCK & CO., INC. (US) | 1988-03-08 | — | — | US | disclosed |
| US-4692441-A | B-LACTAM ANTIBIOTICS | MERCK & CO., INC. (US) | 1987-09-08 | — | — | US | disclosed |
| EP-0214898-A2 | Choline esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities | MERCK & CO. INC. (US) | 1987-03-18 | — | — | EP | disclosed |
| EP-0206947-A2 | Pharmaceutical composition containing choline ester salts for enhancing gastrointestinal tract absorption | MERCK & CO. INC. (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0162764-A1 | Composition and method for enhancing absorption of drugs from gastrointestinal tract using acylcarnitines | MERCK & CO. INC. (US) | 1985-11-27 | — | — | EP | disclosed |
| US-4537772-A | Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines | MERCK & CO., INC. (US) | 1985-08-27 | — | — | US | disclosed |