Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dronabinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 known ✓ | P21554 | 11/20 | 0.75 |
| ▸ | CNR2 | P34972 | 16/20 | 0.75 |
| ▸ | ABHD12 | Q8N2K0 | 3/20 | 0.75 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.75 |
| ▸ | FAAH | O00519 | 2/20 | 0.75 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.75 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | LDHA | P00338 | 1/20 | 0.75 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.75 |
| ▸ | GPR183 | P32249 | 1/20 | 0.75 |
| ▸ | DRD3 | P35462 | 1/20 | 0.75 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.75 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.75 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.67 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.67 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.67 |
| ▸ | TRPV2 | Q9Y5S1 | 3/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24036885 | 0.91 | CNR2 (0.72) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL3686519 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL4609 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL11375978 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL24702729 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL13214137 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL13394311 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL1227386 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL22705549 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL30018684 | 0.86 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166051-A | A support, a membrane over an aperture that excludes red blood cells for forming test strips and analyzing the signal | GENESIS LABS, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-4580440-A | Method of detecting a contraband substance | BRITISH AEROSPACE PUBLIC COMPANY LIMITED, BRACKNELL DIVISION (GB) | 1986-04-08 | — | — | US | disclosed |
| US-4517303-A | Specific binding assays utilizing analyte-cytolysin conjugates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-05-14 | — | — | US | disclosed |