Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 10/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 9/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | HSD3B1 | P14060 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9747868 | 1.00 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL9747689 | 1.00 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8163483 | 1.00 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8163488 | 1.00 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL9747685 | 1.00 | SRD5A1 (0.68) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8158248 | 0.99 | SRD5A1 (0.69) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8158252 | 0.99 | SRD5A1 (0.69) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8156097 | 0.97 | SRD5A1 (0.69) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL8156098 | 0.97 | SRD5A1 (0.69) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| SCHEMBL24503471 | 0.88 | SRD5A1 (0.74) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414490-A2 | 17 Beta-acyl-4-aza-5 alpha-androst-1-ene-3-one as 5 alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1991-02-27 | — | — | EP | claimed |
| US-5120742-A | Androstanes as enzyme inhibitors | MERCK & CO., INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0414490-A2 | 17 Beta-acyl-4-aza-5 alpha-androst-1-ene-3-one as 5 alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1991-02-27 | — | — | EP | disclosed |