Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748286 | 1.00 | MAPT (0.47) | MAPTALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL9748283 | 1.00 | MAPT (0.47) | MAPTALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL9748933 | 0.94 | HSP90AA1 (0.50) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9748938 | 0.94 | HSP90AA1 (0.50) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9748930 | 0.94 | HSP90AA1 (0.50) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL15475400 | 0.92 | HSP90AA1 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9748235 | 0.92 | HSP90AA1 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9748950 | 0.92 | HSP90AA1 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9748228 | 0.92 | HSP90AA1 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11166892 | 0.92 | HSP90AA1 (0.53) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668504-A | Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | claimed |
| US-5147868-A | For selectively inhibiting the metabolism of dipeptidase; useful in mixtures with bactericides | MERCK & CO., INC. (US) | 1992-09-15 | — | — | US | disclosed |
| US-5071843-A | Thienamycin antibiotics with delayed metabolism | MERCK & CO., INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0161546-B1 | COMBINATION OF 2-SUBSTITUTED CARBAPENEMS WITH DIPEPTIDASE INHIBITORS | MERCK & CO. INC. (US) | 1989-12-13 | — | — | EP | disclosed |
| US-4880793-A | BACTERICIDES, UNSATURATED CARBOXYLIC ACID, AMIDES | MERCK & CO., INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4668504-A | Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | disclosed |
| US-4616038-A | BACTERICIDES | MERCK & CO., INC. (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0161546-A1 | Combination of 2-substituted carbapenems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4539208-A | Combination of thienamycin-type antibiotics with dipeptidase inhibitors | MERCK & CO., INC. (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0010573-B1 | NOVEL Z-2-ACYLAMINO-3-MONOSUBSTITUTED PROPENIC ACIDS AND THEIR ESTERS AND SALTS, AND PROCESSES FOR PREPARING THEM | MERCK & CO. INC. (US) | 1983-10-19 | — | — | EP | disclosed |
| EP-0072014-A1 | Combination of 2-substituted penems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0028778-A1 | Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate | MERCK & CO. INC. (US) | 1981-05-20 | — | — | EP | disclosed |
| EP-0010573-A1 | Novel Z-2-acylamino-3-monosubstituted propenic acids and their esters and salts, and processes for preparing them | MERCK & CO. INC. (US) | 1980-05-14 | — | — | EP | disclosed |
| EP-0007614-A1 | An antibacterial composition of thienamycin-type compound and a dipeptidase inhibitor | MERCK & CO. INC. (US) | 1980-02-06 | — | — | EP | disclosed |