Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748941 | 1.00 | HDAC8 (0.47) | HDAC8HDAC6 | |
| SCHEMBL9748949 | 1.00 | HDAC8 (0.47) | HDAC8HDAC6 | |
| SCHEMBL9748411 | 1.00 | HDAC8 (0.47) | HDAC8HDAC6 | |
| SCHEMBL9748416 | 1.00 | HDAC8 (0.47) | HDAC8HDAC6 | |
| SCHEMBL9748954 | 1.00 | HDAC8 (0.47) | HDAC8HDAC6 | |
| SCHEMBL9748968 | 0.98 | — | — | |
| SCHEMBL9748964 | 0.98 | — | — | |
| SCHEMBL9748967 | 0.98 | — | — | |
| SCHEMBL9748241 | 0.94 | — | — | |
| SCHEMBL9748239 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668504-A | Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | claimed |
| US-5147868-A | For selectively inhibiting the metabolism of dipeptidase; useful in mixtures with bactericides | MERCK & CO., INC. (US) | 1992-09-15 | — | — | US | disclosed |
| US-5071843-A | Thienamycin antibiotics with delayed metabolism | MERCK & CO., INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0161546-B1 | COMBINATION OF 2-SUBSTITUTED CARBAPENEMS WITH DIPEPTIDASE INHIBITORS | MERCK & CO. INC. (US) | 1989-12-13 | — | — | EP | disclosed |
| US-4880793-A | BACTERICIDES, UNSATURATED CARBOXYLIC ACID, AMIDES | MERCK & CO., INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4668504-A | Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | disclosed |
| US-4616038-A | BACTERICIDES | MERCK & CO., INC. (US) | 1986-10-07 | — | — | US | disclosed |
| US-4539208-A | Combination of thienamycin-type antibiotics with dipeptidase inhibitors | MERCK & CO., INC. (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0010573-B1 | NOVEL Z-2-ACYLAMINO-3-MONOSUBSTITUTED PROPENIC ACIDS AND THEIR ESTERS AND SALTS, AND PROCESSES FOR PREPARING THEM | MERCK & CO. INC. (US) | 1983-10-19 | — | — | EP | disclosed |