Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9748887 | 1.00 | MME (0.51) | MMENPSR1NAALAD2CYP1A2MMP2 | |
| SCHEMBL17633984 | 0.98 | MME (0.53) | MMENPSR1NAALAD2CYP1A2MMP2 | |
| SCHEMBL8385283 | 0.98 | MME (0.53) | MMENPSR1NAALAD2CYP1A2MMP2 | |
| SCHEMBL31398551 | 0.85 | FOLH1 (0.52) | MMENAALAD2L3MBTL1FOLH1ACE | |
| SCHEMBL31568014 | 0.83 | KMT2A (0.49) | MMP2 | |
| SCHEMBL31568017 | 0.83 | KMT2A (0.49) | MMP2 | |
| SCHEMBL697900 | 0.82 | EPHX1 (0.61) | MMENPSR1NAALAD2CYP1A2MMP2 | |
| SCHEMBL697901 | 0.82 | EPHX1 (0.61) | MMENPSR1NAALAD2CYP1A2MMP2 | |
| Benzene SCHEMBL27636787 | 0.82 | EPHX1 (0.61) | MMENPSR1NAALAD2CYP1A2MMP2 | |
| SCHEMBL8211678 | 0.82 | EPHX1 (0.61) | MMENPSR1NAALAD2CYP1A2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155255-A | PROCESS FOR PRODUCING CYCLOALKENYLALKENES | HOFFMANN-LA ROCHE INC. (US) | 1992-10-13 | — | — | US | disclosed |