Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Icrf-193. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.66 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Icrf-193 SCHEMBL14006976 | 0.81 | TOP2A (1.00) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL18618027 | 0.71 | TOP2A (0.76) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| Acetic Acid SCHEMBL11382699 | 0.69 | FFAR3 (0.50) | ALDH1A1MAPTTDP1PTGS1LMNA | |
| Acetic Acid SCHEMBL9846812 | 0.69 | FFAR3 (0.50) | ALDH1A1MAPTTDP1PTGS1LMNA | |
| Hydrochloric Acid SCHEMBL9154624 | 0.69 | TOP2A (0.50) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL13857354 | 0.68 | TOP2A (0.73) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL14006906 | 0.68 | TOP2A (0.58) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL19505555 | 0.68 | TOP2A (1.00) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| Acetic Acid SCHEMBL6051117 | 0.67 | FFAR3 (0.54) | ALDH1A1MAPTTDP1PTGS1LMNA | |
| Acetic Acid SCHEMBL8325526 | 0.67 | FFAR3 (0.54) | ALDH1A1MAPTTDP1PTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991000729-A2 | BIS-DIOXOPIPERAZINES, AND THEIR USE AS PROTECTING AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-01-24 | — | — | WO | disclosed |