Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654439 | 0.82 | TLR8 (0.46) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL353025 | 0.80 | CYP1A2 (0.59) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2541919 | 0.77 | TLR8 (0.58) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9144151 | 0.77 | TLR8 (0.43) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14957163 | 0.76 | TLR8 (0.42) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21439371 | 0.75 | MCL1 (0.40) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17033307 | 0.75 | TLR8 (0.39) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8013150 | 0.74 | TLR8 (0.41) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1104838 | 0.74 | TLR7 (0.53) | TLR8CYP3A4ADORA3ADORA2AALKBH5 | |
| SCHEMBL9847092 | 0.74 | TLR8 (0.48) | TLR8CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |