SCHEMBL9753444

SCHEMBL9753444

O=C(O)c1cn2c(C(O)c3nnn[nH]3)c(Cl)ccc2n1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9753756 0.84
SCHEMBL9753495 0.81
SCHEMBL8608906 0.80
SCHEMBL9753401 0.80 PTGS1 (0.40) PTGS1PTGS2
SCHEMBL8604751 0.77 PTGS1 (0.38) PTGS1PTGS2
SCHEMBL8607484 0.77 PTGS1 (0.34) PTGS1PTGS2
SCHEMBL8608914 0.77 PTGS1 (0.32) PTGS1PTGS2
SCHEMBL8608070 0.75 PTGS1 (0.43) PTGS1PTGS2
SCHEMBL9753440 0.74
SCHEMBL8605900 0.72 PTGS1 (0.42) PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0436831-A2 Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury G.D. Searle & Co. (US) 1991-07-17 EP claimed
WO-1991008211-A1 IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY G.D. SEARLE & CO. (US) 1991-06-13 WO claimed
EP-0436831-A2 Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury G.D. Searle & Co. (US) 1991-07-17 EP disclosed
WO-1991008211-A1 IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY G.D. SEARLE & CO. (US) 1991-06-13 WO disclosed