Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753611 | 1.00 | GAA (0.58) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL8889397 | 0.83 | GAA (0.60) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL8889403 | 0.83 | GAA (0.60) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL8609864 | 0.82 | GAA (0.68) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL8607711 | 0.81 | GAA (0.64) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL9753595 | 0.80 | GAA (0.61) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL8610256 | 0.80 | GAA (0.71) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL7274660 | 0.79 | GAA (0.75) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL8607723 | 0.79 | GAA (0.67) | GAAMAPK1CYP1A2KDM4EPOLB | |
| SCHEMBL118407 | 0.78 | GAA (0.73) | GAAMAPK1CYP1A2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |