Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 1.00 |
| ▸ | HTR5A | P47898 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.77 |
| ▸ | HTR2C | P28335 | 1/20 | 0.77 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptoline SCHEMBL171755 | 1.00 | NISCH (1.00) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL9480983 | 1.00 | NISCH (1.00) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL12190178 | 1.00 | NISCH (1.00) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL29350043 | 1.00 | NISCH (1.00) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL30213301 | 0.98 | NISCH (0.96) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL8818317 | 0.98 | NISCH (0.96) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL28226558 | 0.98 | NISCH (0.96) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL28477910 | 0.96 | NISCH (0.93) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL29139386 | 0.92 | NISCH (0.84) | NISCHKDM4ENR2E1HTR5AHTR2A | |
| Tryptoline SCHEMBL28856564 | 0.91 | NISCH (0.82) | NISCHKDM4ENR2E1HTR5AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991014184-A1 | BETA CARBOLINES AS VITAL STAINS FOR NEUROTRANSMITTER SYSTEMS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-09-19 | — | — | WO | disclosed |