Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757066 | 0.87 | CYSLTR1 (0.46) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL9756961 | 0.83 | FFAR1 (0.48) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL9757212 | 0.80 | GPBAR1 (0.60) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL7718896 | 0.76 | GPBAR1 (0.90) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL7457682 | 0.76 | GPBAR1 (0.90) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL9757272 | 0.76 | CYSLTR1 (0.60) | GPBAR1ALOX5CYSLTR1CYSLTR2 | |
| SCHEMBL9635483 | 0.74 | CYSLTR1 (0.45) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL10544473 | 0.74 | CYSLTR1 (0.84) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL6088569 | 0.73 | FFAR1 (0.73) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 | |
| SCHEMBL26771305 | 0.73 | GPBAR1 (0.83) | GPBAR1FFAR1AKR1B1ALOX5CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |