Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760564 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| SCHEMBL9760561 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL9721895 | 0.97 | KDM4E (0.41) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL9721904 | 0.97 | KDM4E (0.41) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL9721902 | 0.97 | KDM4E (0.41) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| SCHEMBL9773718 | 0.87 | KDM1A (0.45) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| SCHEMBL6215374 | 0.87 | KDM1A (0.45) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| SCHEMBL9773716 | 0.87 | KDM1A (0.45) | KDM4EALDH1A1MAPTKDM1AMAOA | |
| SCHEMBL2224361 | 0.81 | FUCA1 (0.50) | KDM1AMAOAFUCA1GRIN2BMAOB | |
| SCHEMBL6204106 | 0.78 | KDM1A (0.43) | KDM1AMAOAFUCA1GRIN2BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041454-A | Stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| US-4975439-A | Gastrointestinal motility stimulating properties | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-12-04 | — | — | US | disclosed |