SCHEMBL9761302

SCHEMBL9761302

NCCOCCOCCCOCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.52
NAAA Q02083 2/20 0.49
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
HRH4 Q9H3N8 1/20 0.44
HRH3 Q9Y5N1 1/20 0.44
IDO1 P14902 1/20 0.43
AGXT P21549 1/20 0.42
LTA4H P09960 1/20 0.42
TAAR1 Q96RJ0 2/20 0.41
MAOA P21397 1/20 0.41
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41
CYP2A6 P11509 1/20 0.40
HTR2A P28223 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
LOXL2 Q9Y4K0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21214934 1.00 TSHR (0.52) TSHRNAAATDP1L3MBTL1HRH4
SCHEMBL26813195 0.98 TSHR (0.50) TSHRNAAATDP1L3MBTL1HRH4
SCHEMBL31090653 0.98 TSHR (0.54) TSHRNAAATDP1L3MBTL1HRH4
SCHEMBL26813217 0.98 TSHR (0.54) TSHRNAAATDP1L3MBTL1HRH4
Hydrochloric Acid SCHEMBL28855420 0.96 TSHR (0.52) TSHRNAAATDP1L3MBTL1HRH4
SCHEMBL27375031 0.94 TSHR (0.54) TSHRNAAATDP1L3MBTL1HRH4
SCHEMBL25227691 0.94 TSHR (0.58) TSHRNAAAIDO1AGXTLTA4H
SCHEMBL6554989 0.94 TSHR (0.58) TSHRNAAAIDO1AGXTLTA4H
SCHEMBL4446579 0.94 TSHR (0.58) TSHRNAAAIDO1AGXTLTA4H
SCHEMBL12013285 0.94 TSHR (0.58) TSHRNAAAIDO1AGXTLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3731869-A1 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2020-11-04 EP disclosed
US-5026863-A Medicinal products in racemic or enantiomorph form; calcium channel blockers. hypotensive agents, cardiovascular disorders ADIR ET COMPAGNIE (FR) 1991-06-25 US disclosed
US-4983740-A Multistep; from 2- 2-/2-chloroethoxy/ethoxy!ethanol and potassium phthalimide ADIR ET COMPAGNIE (FR) 1991-01-08 US disclosed
US-4870091-A CALCIUM CHANNEL BLOCKERS ADIR ET CIE (FR) 1989-09-26 US disclosed