SCHEMBL9762745

SCHEMBL9762745

CC[C@H]1CC[C@H](C2CCC(c3ccc(CC(F)(F)F)cc3)CC2)CC1.C[C@H]1CC[C@H](C2CCC(c3ccc(CC(F)(F)F)cc3)CC2)CC1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 8/20 0.41
CYP2C9 P11712 3/20 0.36
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
MEN1 O00255 1/20 0.35
MAPK1 P28482 1/20 0.35
KMT2A Q03164 1/20 0.35
SPHK1 Q9NYA1 3/20 0.34
ESR1 P03372 5/20 0.33
CYP3A4 P08684 2/20 0.33
CACNA1G O43497 1/20 0.32
CACNA1H O95180 1/20 0.32
CACNA1I Q9P0X4 1/20 0.32
PDE2A O00408 2/20 0.32
CYP2D6 P10635 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9762751 1.00 ESR2 (0.41) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9762748 1.00 ESR2 (0.41) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9315756 0.94 CYP2C9 (0.39) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9315774 0.94 CYP2C9 (0.39) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9315767 0.94 CYP2C9 (0.39) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9314978 0.93 ESR2 (0.47) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9314982 0.93 ESR2 (0.47) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9314991 0.93 ESR2 (0.47) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL15043501 0.88 ESR2 (0.52) ESR2CYP2C9ALDH1A1LMNAMAPT
SCHEMBL9313540 0.84 CYP2C9 (0.51) ESR2CYP2C9ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0425622-A1 MESOGENIC COMPOUNDS. MERCK PATENT GMBH (DE) 1991-05-08 EP disclosed