SCHEMBL9762942

SCHEMBL9762942

OCCC=Cc1cc(OCc2ccccc2)cc(OCc2ccccc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.58
CYP1A1 P04798 1/20 0.58
CYP19A1 P11511 1/20 0.58
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
KDM4E B2RXH2 1/20 0.49
ALDH1A1 P00352 1/20 0.49
PKM P14618 1/20 0.49
LCK P06239 1/20 0.49
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49
MAOB P27338 3/20 0.48
MAOA P21397 2/20 0.48
CCNB2 O95067 1/20 0.47
CDK1 P06493 1/20 0.47
CDK4 P11802 1/20 0.47
CCNB1 P14635 1/20 0.47
CCND1 P24385 1/20 0.47
CCNB3 Q8WWL7 1/20 0.47
ALOX5 P09917 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9763042 0.90 CYP1A2 (0.55) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL9763039 0.90 CYP1A2 (0.55) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL6582106 0.86 GSK3B (0.60) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL6582102 0.86 GSK3B (0.60) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL6666536 0.85 AKT1 (0.48) CYP1A2CYP1A1CYP19A1KDM4EALDH1A1
SCHEMBL9763045 0.84 CYP1A1 (0.49) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL9763041 0.84 CYP1A1 (0.49) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL24633372 0.81 CYP1A2 (0.57) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL9762617 0.81 CYP1A1 (0.51) CYP1A2CYP1A1CYP19A1MEN1KMT2A
SCHEMBL23639023 0.81 CYP1A1 (0.51) CYP1A2CYP1A1CYP19A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4990505-A Treating asthma, bronchitis; adrenergic stimulants GLAXO GROUP LIMITED (GB) 1991-02-05 US disclosed
US-4853382-A TREATING ASTHMA AND BRONCHITIS GLAXO GROUP LIMITED (GB) 1989-08-01 US disclosed
US-4730008-A STIMULANT FOR BETA-ADRENORECEPTORS GLAXO GROUP LIMITED (GB) 1988-03-08 US disclosed
EP-0178919-A2 Aminophenol derivatives GLAXO GROUP LIMITED (GB) 1986-04-23 EP disclosed