Sugi Predict

Sugi Predict / Compounds / SCHEMBL976669

SCHEMBL976669

SCHEMBL976669

CC(N)c1nc2sccn2c(=O)c1-c1cc(F)cc(F)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 8/20 0.47
▸ CYP1A2 P05177 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ PIK3CG P48736 1/20 0.37
▸ ERBB2 P04626 2/20 0.35
▸ PIM1 P11309 2/20 0.35
▸ FGFR1 P11362 2/20 0.35
▸ FLT4 P35916 2/20 0.35
▸ MAPK8 P45983 2/20 0.35
▸ MAPK9 P45984 2/20 0.35
▸ CSNK1D P48730 2/20 0.35
▸ LIMK1 P53667 2/20 0.35
▸ DYRK1A Q13627 2/20 0.35
▸ PRKD2 Q9BZL6 2/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ EGFR P00533 1/20 0.35
▸ FYN P06241 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ KDR P35968 1/20 0.35
▸ CDC42BPA Q5VT25 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL954043 0.89 PIK3CD (0.59) PIK3CDCYP1A2TDP1PIK3CG
SCHEMBL975956 0.82 PIK3CD (0.56) PIK3CDCYP1A2TDP1MAPTHSD17B10
SCHEMBL2036689 0.82 MAPK8 (0.41) PIK3CDCYP1A2TDP1PIK3CGERBB2
SCHEMBL15732474 0.82 PIK3CD (0.42) PIK3CDCYP1A2TDP1PIK3CGERBB2
SCHEMBL637327 0.81 TDP1 (0.55) CYP1A2TDP1MAPK1PKMMAPT
SCHEMBL975357 0.77 PIK3CD (0.59) PIK3CDPIK3CGKDM4EALDH1A1HPGD
Hydrochloric Acid SCHEMBL977139 0.76 PIK3CD (0.58) PIK3CDPIK3CGKDM4E
SCHEMBL975128 0.76 PIK3CD (0.60) PIK3CDPIK3CG
SCHEMBL12922271 0.75 TDP1 (0.61) PIK3CDCYP1A2TDP1LIMK1DYRK1A
SCHEMBL956806 0.71 PIK3CD (0.60) PIK3CDPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11401280-B2 Pyrimidinones as PI3K inhibitors INCYTE HOLDINGS CORPORATION (US) 2022-08-02 — — US disclosed
US-20210253601-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE HOLDINGS CORPORATION 2021-08-19 — — US disclosed
US-20210253601-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE HOLDINGS CORPORATION 2021-08-19 — — US disclosed
US-10829502-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2020-11-10 — — US disclosed
US-10829502-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2020-11-10 — — US disclosed
US-20200123176-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION 2020-04-23 — — US disclosed
US-20200123176-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION 2020-04-23 — — US disclosed
US-10428087-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2019-10-01 — — US disclosed
US-10428087-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2019-10-01 — — US disclosed
US-20180362546-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION 2018-12-20 — — US disclosed
EP-2845856-A1 Pyrimidinones as PI3K inhibitors Incyte Corporation (US) 2015-03-11 — — EP disclosed
US-8940752-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2015-01-27 — — US disclosed
US-8940752-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2015-01-27 — — US disclosed
US-8940752-B2 Pyrimidinones as PI3K inhibitors INCYTE CORPORATION (US) 2015-01-27 — — US disclosed
EP-2448938-B1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORP (US) 2014-05-28 — — EP disclosed
EP-2448938-B1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORP (US) 2014-05-28 — — EP disclosed
US-20140121222-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2014-05-01 — — US disclosed
US-20110015212-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION 2011-01-20 — — US disclosed
US-20110015212-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION 2011-01-20 — — US disclosed
US-20110015212-A1 PYRIMIDINONES AS PI3K INHIBITORS INCYTE CORPORATION 2011-01-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11401280-B2 Pyrimidinones as PI3K inhibitors PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-10428087-B2 Pyrimidinones as PI3K inhibitors PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-20140121222-A1 PYRIMIDINONES AS PI3K INHIBITORS PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-20210253601-A1 PYRIMIDINONES AS PI3K INHIBITORS PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-10829502-B2 Pyrimidinones as PI3K inhibitors PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-20180362546-A1 PYRIMIDINONES AS PI3K INHIBITORS PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-20200123176-A1 PYRIMIDINONES AS PI3K INHIBITORS PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885
US-20110015212-A1 PYRIMIDINONES AS PI3K INHIBITORS PIK3CA, PIK3CD, PIK3CB PIK3CD 2/4885CYP1A2 2027/4885TDP1 767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.