Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.77 |
| ▸ | PPARA | Q07869 | 2/20 | 0.63 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | TACR2 | P21452 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SHBG | P04278 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531761 | 1.00 | KAT8 (0.77) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL8527291 | 1.00 | KAT8 (0.77) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL6582694 | 1.00 | KAT8 (0.77) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL15765290 | 1.00 | KAT8 (0.77) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL207879 | 1.00 | KAT8 (0.77) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL6582850 | 1.00 | KAT8 (0.77) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL11517335 | 0.98 | KAT8 (0.74) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL1415882 | 0.93 | KAT8 (0.67) | KAT8PPARAHSD17B10ALDH1A1LCK | |
| SCHEMBL28445615 | 0.89 | KAT8 (0.79) | KAT8PPARAESR1ADRA2AADORA3 | |
| SCHEMBL2529442 | 0.87 | KAT8 (1.00) | KAT8PPARAEGFRLCKPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981989-A | Antihypertensive phosphate derivatives and intermediates thereof | AMERICAN CYANAMID COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4894367-A | CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1990-01-16 | — | — | US | disclosed |
| US-4883816-A | SULFONYL DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1989-11-28 | — | — | US | disclosed |
| US-4762942-A | AMINO SUBSTITUTED, INNER SALTS | AMERICAN CYANAMID CO. (US) | 1988-08-09 | — | — | US | disclosed |