Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 10/20 | 0.47 |
| ▸ | CES2 | O00748 | 7/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720587 | 0.82 | CES1 (0.48) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL28327257 | 0.79 | CES1 (0.50) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL18982981 | 0.79 | CES1 (0.50) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL2292151 | 0.78 | CES1 (0.45) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL11172533 | 0.78 | CES1 (0.41) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL5031584 | 0.77 | CES1 (0.52) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL8459655 | 0.77 | CTNNB1 (0.61) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL11308508 | 0.77 | CES1 (0.52) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL27714041 | 0.77 | CES1 (0.52) | CES1CES2SRCALDH1A1GSK3B | |
| SCHEMBL1874832 | 0.76 | CES1 (0.56) | CES1CES2SRCALDH1A1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059601-A | IMIDAZOLONE DERIVATIVES WITH ACTIVITY ON CENTRAL NERVOUS SYSTEM AND ANTIHYPERTENSIVE ACTIVITY, PREPARATION METHODS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1991-10-22 | — | — | US | disclosed |