Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | EBP | Q15125 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405681 | 1.00 | USP2 (0.38) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7697140 | 0.91 | USP2 (0.40) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL5027314 | 0.90 | PTPN1 (0.37) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL5027320 | 0.90 | PTPN1 (0.37) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7128673 | 0.90 | PTPN1 (0.37) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL8212261 | 0.90 | PTPN1 (0.37) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7698278 | 0.90 | BACE1 (0.39) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7707297 | 0.90 | PTPN1 (0.37) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7697228 | 0.89 | PTPN1 (0.38) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL6405678 | 0.88 | USP2 (0.49) | USP2ALDH1A1CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041432-A | Enzyme inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| US-5034548-A | Enzyme inhibitors for reducing serum cholesterol | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0276823-A2 | 14,15-Substituted lanosterols and their use as hypocholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |