Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.69 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | CRYAB | P02511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769589 | 1.00 | HMGCR (0.69) | HMGCRPTGESACLYACACAUSP2 | |
| SCHEMBL9769632 | 0.84 | USP2 (0.63) | HMGCRUSP2MEN1ALDH1A1MAPT | |
| SCHEMBL13384620 | 0.83 | HMGCR (0.79) | HMGCRPTGESACLYACACAUSP2 | |
| SCHEMBL9769594 | 0.82 | HMGCR (0.49) | HMGCRPTGESACLYACACAPTPN1 | |
| SCHEMBL9769587 | 0.82 | HMGCR (0.49) | HMGCRPTGESACLYACACAPTPN1 | |
| SCHEMBL9769631 | 0.80 | HMGCR (0.69) | HMGCRPTGESACLYACACAUSP2 | |
| SCHEMBL9766765 | 0.80 | HMGCR (0.74) | HMGCRPTGESACLYACACAUSP2 | |
| SCHEMBL9766761 | 0.80 | HMGCR (0.74) | HMGCRPTGESACLYACACAUSP2 | |
| SCHEMBL9769626 | 0.80 | HMGCR (0.69) | HMGCRPTGESACLYACACAUSP2 | |
| SCHEMBL9769636 | 0.79 | HMGCR (0.68) | HMGCRPTGESACLYACACAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041432-A | Enzyme inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| US-5034548-A | Enzyme inhibitors for reducing serum cholesterol | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0276823-A2 | 14,15-Substituted lanosterols and their use as hypocholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |