Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BID | P55957 | 3/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
| ▸ | IAPP | P10997 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | FABP3 | P05413 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL9769931 | 0.88 | HMGB1 (0.50) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL11169533 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL31372911 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| Zinc Ion SCHEMBL10581371 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL11123537 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| Zinc Ion SCHEMBL10584384 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL11125907 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL3517528 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL9790326 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| Zinc Ion SCHEMBL7084049 | 0.88 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5013833-A | Process for preparing cefuroxime axetil | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |
| US-4994567-A | Purification by recovering from solution by roller drying | GALAXO GROUP LIMITED (GB) | 1991-02-19 | — | — | US | disclosed |
| US-4820833-A | PURIFICATION BY SPRAY DRYING PRECIPITATION, FREEZE DRYING; CEPHALOSPORINS | GLAXO GROUP LIMITED (GB) | 1989-04-11 | — | — | US | disclosed |
| EP-0107276-B1 | NOVEL FORM OF CEFUROXIME ESTER, PROCESS FOR ITS PREPARATION AND COMPOSITION CONTAINING IT | GLAXO GROUP LIMITED (GB) | 1987-10-07 | — | — | EP | disclosed |
| US-4562181-A | INCREASED ABSORPTION VIA THE GASTROINTESTINAL TRACT, ALLOWING FOR ORAL OR RECTAL ADMINISTRATION | GLAXO GROUP LIMITED (GB) | 1985-12-31 | — | — | US | disclosed |
| EP-0107276-A2 | Novel form of cefuroxime ester, process for its preparation and composition containing it | GLAXO GROUP LIMITED (GB) | 1984-05-02 | — | — | EP | disclosed |