2,6-Dibenzylidenecyclohexanone

2,6-Dibenzylidenecyclohexanone

SCHEMBL977260

O=C1/C(=C\c2ccccc2)CCC/C1=C\c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 1.00
F3 P13726 2/20 1.00
MGAM O43451 3/20 0.79
GAA P10253 3/20 0.79
SI P14410 3/20 0.79
MGAM2 Q2M2H8 3/20 0.79
HTT P42858 4/20 0.74
ALDH1A1 P00352 2/20 0.74
MAPT P10636 5/20 0.72
MEN1 O00255 1/20 0.72
LMNA P02545 1/20 0.72
KMT2A Q03164 1/20 0.72
MIF P14174 1/20 0.71
EGFR P00533 1/20 0.68
HSD11B1 P28845 2/20 0.66
RAB9A P51151 2/20 0.66
SMN1; SMN2 Q16637 2/20 0.66
CYP2C9 P11712 1/20 0.66
NPC1 O15118 1/20 0.66
HSP90AA1 P07900 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2,6-Dibenzylidenecyclohexanone SCHEMBL12948726 1.00 CYP1A2 (1.00) CYP1A2F3MGAMGAASI
2,6-Dibenzylidenecyclohexanone SCHEMBL977261 1.00 CYP1A2 (1.00) CYP1A2F3MGAMGAASI
2,6-Dibenzylidenecyclohexanone SCHEMBL11732505 0.98 CYP1A2 (0.96) CYP1A2F3MGAMGAASI
2,6-Dibenzylidenecyclohexanone SCHEMBL11732500 0.98 CYP1A2 (0.96) CYP1A2F3MGAMGAASI
SCHEMBL3263383 0.96 CYP1A2 (0.92) CYP1A2F3MGAMGAASI
SCHEMBL3263387 0.96 CYP1A2 (0.92) CYP1A2F3MGAMGAASI
SCHEMBL11789316 0.94 CYP1A2 (0.88) CYP1A2F3MGAMGAASI
SCHEMBL11789309 0.94 CYP1A2 (0.88) CYP1A2F3MGAMGAASI
2,6-Dibenzylidenecyclohexanone SCHEMBL5688633 0.92 CYP1A2 (0.85) CYP1A2F3MGAMGAASI
SCHEMBL23633272 0.91 CYP1A2 (1.00) CYP1A2F3MGAMGAASI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5972562-A Visible radiation-curable solder resist compositions, and method for forming solder resist patterns FUJITSU LIMITED (JP) 1999-10-26 US claimed
US-20160311386-A1 ELEMENT OF AN ENGINE COMPARTMENT OF A MOTOR VEHICLE AND METHOD OF PROTECTING THE ELEMENT AGAINST CHEMICAL ATTACKS FROM A METAL HALIDE HUTCHINSON (FR) 2016-10-27 US disclosed
EP-3083245-A1 ELEMENT OF AN ENGINE COMPARTMENT OF A MOTOR VEHICLE AND METHOD OF PROTECTING THE ELEMENT AGAINST CHEMICAL ATTACKS FROM A METAL HALIDE Hutchinson (FR) 2016-10-26 EP disclosed
US-20160039734-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC UNM (US) 2016-02-11 US disclosed
US-9204652-B2 Antibacterial agent, substrate surface treatment method using the same, antibacterial agent composition, and substrate surface treatment method using the same CENTRAL GLASS COMPANY, LIMITED (JP) 2015-12-08 US disclosed
US-9187397-B2 Therapeutic curcumin derivatives STC.UNM (US) 2015-11-17 US disclosed
WO-2015092158-A1 ELEMENT OF AN ENGINE COMPARTMENT OF A MOTOR VEHICLE AND METHOD OF PROTECTING THE ELEMENT AGAINST CHEMICAL ATTACKS FROM A METAL HALIDE HUTCHINSON (FR) 2015-06-25 WO disclosed
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC.UNM 2015-01-08 US disclosed
US-8841326-B2 Therapeutic curcumin derivatives STC.UNM (US) 2014-09-23 US disclosed
EP-2622960-A1 ANTIBACTERIAL AGENT, SUBSTRATE SURFACE TREATMENT METHOD USING THE SAME, ANTIBACTERIAL AGENT COMPOSITION, AND SUBSTRATE SURFACE TREATMENT METHOD USING THE SAME Central Glass Company, Limited (JP) 2013-08-07 EP disclosed
EP-1242352-A2 CHALCONE AND ITS ANALOGS AS AGENTS FOR THE INHIBITION OF ANGIOGENESIS AND RELATED DISEASE STATES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2002-09-25 EP disclosed
US-20020040029-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states BOWEN, J. PHILLIP 2002-04-04 US disclosed
WO-2001046110-A2 CHALCONE AND ITS ANALOGS AS AGENTS FOR THE INHIBITION OF ANGIOGENESIS AND RELATED DISEASE STATES THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2001-06-28 WO disclosed
US-5972562-A Visible radiation-curable solder resist compositions, and method for forming solder resist patterns FUJITSU LIMITED (JP) 1999-10-26 US disclosed
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP disclosed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US disclosed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO disclosed
US-4004007-A ANTIINFLAMMATORY AGENTS E. R. SQUIBB & SONS, INC. (US) 1977-01-18 US disclosed
US-3957762-A CENTRAL NERVOUS SYSTEM DEPRESSANTS E. R. SQUIBB & SONS, INC. (US) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020040029-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states FLT1, FLT4, VEGFA CYP1A2 795/4885F3 739/4885MGAM 1552/4885
US-20160039734-A1 THERAPEUTIC CURCUMIN DERIVATIVES FABP2, GLS2, FABP1 CYP1A2 2544/4885F3 4781/4885MGAM 4452/4885
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES FABP2, GLS2, FABP1 CYP1A2 2544/4885F3 4781/4885MGAM 4452/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.