Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9776921 | 0.99 | NPC1 (0.61) | NPC1LMNAPKMNFKB1RAB9A | |
| Hydrochloric Acid SCHEMBL9776836 | 0.99 | NPC1 (0.61) | NPC1LMNAPKMNFKB1RAB9A | |
| Hydrochloric Acid SCHEMBL9776694 | 0.90 | NPC1 (0.55) | NPC1LMNAPKMNFKB1RAB9A | |
| Hydrochloric Acid SCHEMBL9776710 | 0.88 | EGFR (0.63) | — | |
| Hydrochloric Acid SCHEMBL9776722 | 0.86 | NPC1 (0.66) | NPC1LMNAPKMNFKB1RAB9A | |
| SCHEMBL9776764 | 0.85 | — | — | |
| SCHEMBL9508870 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL9776934 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL9776718 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL9811774 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064833-A | Substituted quinazoline derivatives for use in gastrointestinal diseases | SMITHKLINE BEECHAM INTERCREDIT B.V. (GB) | 1991-11-12 | — | — | US | claimed |
| EP-0322133-B1 | QUINAZOLINE DERIVATIVES | SmithKline Beecham Intercredit B.V. (NL) | 1991-05-22 | — | — | EP | claimed |
| EP-0322133-A1 | Quinazoline derivatives | SmithKline Beecham Intercredit B.V. (NL) | 1989-06-28 | — | — | EP | claimed |