Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 14/20 | 0.61 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802086 | 0.90 | AKR1B1 (0.61) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL8803653 | 0.87 | AKR1B1 (0.58) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL9378243 | 0.87 | AKR1B1 (0.58) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL8802350 | 0.86 | AKR1B1 (0.56) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL9589559 | 0.86 | AKR1B1 (0.55) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL8803259 | 0.85 | AKR1B1 (0.81) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL8803129 | 0.85 | AKR1B1 (0.56) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL9777777 | 0.83 | AKR1B1 (0.75) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL8802491 | 0.83 | AKR1B1 (0.54) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL8803055 | 0.80 | AKR1B1 (0.75) | AKR1B1AKR1A1AKR1B10GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458549-A1 | N-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5045544-A | Preventing or relieving neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |