Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.61 |
| ▸ | SMO | Q99835 | 6/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9778388 | 0.84 | PARP1 (0.52) | MEN1KMT2AMAPK10SMOFLT3 | |
| SCHEMBL9778394 | 0.81 | PARP1 (0.49) | MAPK10FLT3ALDH1A1MAPTTNKS | |
| SCHEMBL4065876 | 0.80 | FLT3 (0.58) | MAPK10FLT3ALDH1A1MAPTLMNA | |
| SCHEMBL3340474 | 0.78 | KIT (0.53) | ALDH1A1MAPTKITTNKSPARP1 | |
| SCHEMBL1597230 | 0.77 | MAPK10 (0.83) | MAPK10FLT3IGF1RFGFR1FGFR2 | |
| SCHEMBL1597233 | 0.77 | MAPK10 (0.83) | MAPK10FLT3IGF1RFGFR1FGFR2 | |
| SCHEMBL3067812 | 0.77 | HPGD (0.55) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL18228562 | 0.77 | HPGD (0.55) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL1545498 | 0.76 | CDC7 (0.53) | MAPK10FLT3FGFR1ALDH1A1PARP1 | |
| SCHEMBL9778831 | 0.76 | PARP1 (0.44) | MAPK10FLT3ALDH1A1MAPTTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5077405-A | Condensation of corresponding phenylsulfonyl compound with condensation agent, cyanation, reduction | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0417653-A1 | 3-(1-Substituted-4-piperazinyl)-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | disclosed |