Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976354 | 0.86 | PDGFRB (0.45) | CSNK1EPDE10APDGFRB | |
| SCHEMBL975387 | 0.85 | HDAC1 (0.47) | HDAC1HDAC2HDAC3 | |
| SCHEMBL978824 | 0.80 | CSNK1E (0.47) | HDAC2CSNK1EPDE10APDGFRB | |
| SCHEMBL978827 | 0.79 | HDAC2 (0.42) | HDAC1HDAC2HDAC3 | |
| SCHEMBL977972 | 0.79 | HDAC3 (0.55) | HDAC1HDAC2HDAC3 | |
| SCHEMBL975412 | 0.77 | HDAC3 (0.55) | HDAC1HDAC2HDAC3 | |
| SCHEMBL978005 | 0.71 | PDE10A (0.41) | CSNK1EPDE10A | |
| SCHEMBL978143 | 0.71 | CSNK1E (0.43) | HDAC1HDAC2CSNK1EPDE10A | |
| SCHEMBL977443 | 0.69 | TRPV1 (0.51) | CSNK1E | |
| SCHEMBL979192 | 0.67 | NAMPT (0.42) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440830-B2 | Tetrahydro-fused pyridines as histone deacetylase inhibitors | 4SC AG (DE) | 2013-05-14 | — | — | US | disclosed |
| EP-2197552-B1 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2012-11-21 | — | — | EP | disclosed |
| US-20110021494-A1 | NOVEL TETRAHYDRO-FUSED PYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2011-01-27 | — | — | US | disclosed |
| EP-2197552-A2 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009037001-A2 | NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021494-A1 | NOVEL TETRAHYDRO-FUSED PYRIDINES AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC2 6/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.