Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10886244 | 0.96 | MEN1 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10886551 | 0.95 | MEN1 (0.54) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10889513 | 0.95 | MEN1 (0.54) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10887690 | 0.95 | MEN1 (0.54) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10889251 | 0.91 | KMT2A (0.50) | MEN1KMT2ASMN1; SMN2LMNAPPARA | |
| SCHEMBL9784527 | 0.89 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2LMNAPPARA | |
| SCHEMBL11140628 | 0.89 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2LMNAPPARA | |
| SCHEMBL10891208 | 0.88 | HDAC6 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10890123 | 0.88 | KDM4E (0.53) | HDAC6HDAC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11138241 | 0.87 | SMN1; SMN2 (0.56) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5003106-A | Antiatherosclerotic ureas and thioureas | AMERICAN CYANAMID COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| US-4623662-A | ANTICHOLESTEROL, ANTILIPEMIC | AMERICAN CYANAMID COMPANY (US) | 1986-11-18 | — | — | US | disclosed |