SCHEMBL9787403

SCHEMBL9787403

CCOC(=O)C1=C(C)NC(Cn2ccnc2)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 12/20 0.68
CACNA1D Q01668 12/20 0.68
CACNA1S Q13698 12/20 0.68
CACNA1C Q13936 12/20 0.68
ADORA3 P0DMS8 1/20 0.68
HIF1A Q16665 3/20 0.64
MEN1 O00255 2/20 0.64
CYP1A2 P05177 2/20 0.64
CYP3A4 P08684 2/20 0.64
CYP2C9 P11712 2/20 0.64
CYP2C19 P33261 2/20 0.64
KMT2A Q03164 2/20 0.64
MAPT P10636 2/20 0.64
LMNA P02545 1/20 0.64
POLB P06746 1/20 0.64
MAPK1 P28482 1/20 0.64
GPR55 Q9Y2T6 1/20 0.64
CYP2D6 P10635 1/20 0.64
TSHR P16473 1/20 0.64
NFKB1 P19838 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9787339 0.96 CACNA1F (0.62) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9787465 0.92 HIF1A (0.62) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9787302 0.92 CACNA1F (0.66) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9787472 0.91 CACNA1F (0.57) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9787287 0.90 MEN1 (0.61) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9192866 0.89 HIF1A (0.61) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9197456 0.89 CACNA1C (0.55) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9191537 0.89 HIF1A (0.61) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9787471 0.88 HIF1A (0.57) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9787318 0.88 HIF1A (0.59) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5068337-A Dihydrodicarboxypyridine as anticoagulants JOHN WYETH & BROTHER LIMITED (GB) 1991-11-26 US claimed
EP-0172029-B1 1,4-DIHYDROPYRIDINES JOHN WYETH & BROTHER LIMITED (GB) 1991-02-27 EP claimed
EP-0172029-A1 1,4-Dihydropyridines JOHN WYETH & BROTHER LIMITED (GB) 1986-02-19 EP claimed
US-5068337-A Dihydrodicarboxypyridine as anticoagulants JOHN WYETH & BROTHER LIMITED (GB) 1991-11-26 US disclosed
EP-0172029-B1 1,4-DIHYDROPYRIDINES JOHN WYETH & BROTHER LIMITED (GB) 1991-02-27 EP disclosed
EP-0172029-A1 1,4-Dihydropyridines JOHN WYETH & BROTHER LIMITED (GB) 1986-02-19 EP disclosed