Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.66 |
| ▸ | FLT3 | P36888 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | DAO | P14920 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923977 | 0.84 | IDO1 (0.68) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL7844858 | 0.82 | IDO1 (0.66) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL2730199 | 0.82 | IDO1 (0.66) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL30148164 | 0.82 | IDO1 (0.66) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL9098845 | 0.82 | IDO1 (0.66) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL30148093 | 0.82 | IDO1 (0.66) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL9100296 | 0.81 | IDO1 (0.64) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL28414304 | 0.81 | IDO1 (0.64) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL10777097 | 0.81 | MAOB (0.49) | IDO1FLT3KDM4EHSD17B10MAPT | |
| SCHEMBL17287276 | 0.79 | IDO1 (1.00) | IDO1FLT3KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259085-B1 | 2-GUANIDINO-4-ARYLTHIAZOLES FOR TREATMENT OF PEPTIC ULCERS | PFIZER INC. (US) | 1991-08-21 | — | — | EP | disclosed |
| US-5026715-A | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0259085-A1 | 2-Guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1988-03-09 | — | — | EP | disclosed |