Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY5 | O95622 | 13/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | CHKA | P35790 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045720 | 1.00 | ADCY5 (1.00) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL14956936 | 1.00 | ADCY5 (1.00) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL6045721 | 1.00 | ADCY5 (1.00) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL6045709 | 1.00 | ADCY5 (1.00) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL6045679 | 1.00 | ADCY5 (1.00) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL6045706 | 0.86 | ADCY5 (0.76) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL6045812 | 0.86 | ADCY5 (0.76) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL19714899 | 0.85 | ADCY5 (0.73) | ADCY5ADORA2ACHKACYP1A2CYP3A4 | |
| SCHEMBL19714823 | 0.85 | ADCY5 (0.73) | ADCY5CHKA | |
| SCHEMBL19714847 | 0.84 | ADCY5 (0.72) | ADCY5CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871735-B2 | Methods and compositions for providing cardiac protection | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130131005-A1 | METHODS AND COMPOSITIONS FOR PROVIDING CARDIAC PROTECTION | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2013-05-23 | — | — | US | disclosed |
| US-20110021453-A1 | Methods and compositions for providing cardiac protection | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2011-01-27 | — | — | US | disclosed |
| WO-2009099676-A1 | TYPE 5 ADENYLYL CYCLASE INHIBITORS FOR PROVIDING CARDIAC PROTECTION | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2009-08-13 | — | — | WO | disclosed |