Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 3/20 | 0.57 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL1537335 | 0.98 | SLC22A1 (0.55) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL1756146 | 0.98 | SLC22A1 (0.60) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL24419 | 0.98 | SLC22A1 (0.60) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL317532 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL333475 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL28112570 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL1072246 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL10581121 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL2313513 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 | |
| Tetrabuthylammonium SCHEMBL7396013 | 0.95 | SLC22A1 (0.57) | SLC22A1SLC22A2TP53TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037975-A | Antibiotics | ELI LILLY AND COMPANY (US) | 1991-08-06 | — | — | US | disclosed |
| US-4939249-A | HEATING CEPHALOSPORIN 1,1-DIOXIDE IN SOLVENT WITH FREE RADICAL INITIATOR | ELI LILLY AND COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0359540-A2 | Process for 1-carba(dethia) cephalosporins | ELI LILLY AND COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |