Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.42 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KCNN2 | Q9H2S1 | 3/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.39 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797246 | 0.89 | KMT2A (0.49) | KMT2AMCHR1MTNR1BGRIN2CSLC18A2 | |
| Hydrochloric Acid SCHEMBL9797418 | 0.88 | KMT2A (0.48) | KMT2AMCHR1MTNR1BGRIN2CSLC18A2 | |
| SCHEMBL9797438 | 0.85 | CYP3A4 (0.51) | KMT2AMCHR1MTNR1BGRIN2CMEN1 | |
| SCHEMBL9797199 | 0.85 | KMT2A (0.46) | KMT2AMCHR1MTNR1BGRIN2CSLC18A2 | |
| SCHEMBL9154107 | 0.84 | KMT2A (0.48) | KMT2AMCHR1MTNR1BGRIN2CSLC18A2 | |
| Hydrochloric Acid SCHEMBL9797211 | 0.84 | CYP3A4 (0.50) | KMT2AMCHR1MTNR1BGRIN2CMEN1 | |
| SCHEMBL9797190 | 0.83 | SLC6A2 (0.41) | GRIN1GRIN2BKCNH2 | |
| SCHEMBL11161276 | 0.78 | SLC6A4 (0.43) | KMT2AMCHR1 | |
| SCHEMBL9797312 | 0.77 | KMT2A (0.52) | KMT2AMCHR1MTNR1BGRIN2CSLC18A2 | |
| Hydrochloric Acid SCHEMBL10954861 | 0.77 | SLC6A4 (0.42) | KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | claimed |
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |