Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.66 |
| ▸ | POLA1 | P09884 | 2/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGAV | P06756 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | ALB | P02768 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9798551 | 1.00 | PDE3A (0.66) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL23724058 | 1.00 | PDE3A (0.66) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL13160992 | 0.94 | PDE3A (0.63) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL21849039 | 0.94 | PDE3A (0.63) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL24703970 | 0.94 | PDE3A (0.63) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL24703971 | 0.94 | PDE3A (0.63) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL17770788 | 0.93 | PDE3A (0.62) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL4939566 | 0.91 | PDE3A (0.64) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL4931963 | 0.90 | PDE3A (0.62) | PDE3APDE4DSLC29A1POLA1ITGB3 | |
| SCHEMBL18078684 | 0.89 | PDE3A (0.69) | PDE3APDE4DSLC29A1POLA1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814438-A | Immunoglobulin conjugates of 2',2'-difluronucleosides | ELI LILLY AND COMPANY (US) | 1989-03-21 | — | — | US | claimed |
| EP-0272891-A2 | Immunoglobulin conjugates | ELI LILLY AND COMPANY (US) | 1988-06-29 | — | — | EP | claimed |
| US-4994558-A | With difluoronucleosides; antitumor, anticancer agents | ELI LILLY AND COMPANY (US) | 1991-02-19 | — | — | US | disclosed |
| US-4814438-A | Immunoglobulin conjugates of 2',2'-difluronucleosides | ELI LILLY AND COMPANY (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0272891-A2 | Immunoglobulin conjugates | ELI LILLY AND COMPANY (US) | 1988-06-29 | — | — | EP | disclosed |