Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.59 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.52 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9798287 | 0.80 | PNP (0.57) | HSP90AB1HSP90AA1 | |
| SCHEMBL3396283 | 0.79 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14568306 | 0.78 | HSP90AB1 (0.77) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3396202 | 0.77 | HSP90AB1 (0.73) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3392317 | 0.76 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1 | |
| SCHEMBL3393055 | 0.76 | HSP90AB1 (0.54) | HSP90AB1HSP90AA1 | |
| SCHEMBL3396492 | 0.76 | HSP90AB1 (0.76) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL27854926 | 0.75 | CDK1 (0.71) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3396346 | 0.75 | HSP90AB1 (0.67) | HSP90AB1HSP90AA1 | |
| SCHEMBL3396801 | 0.75 | HSP90AB1 (0.71) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051429-A | For treatment of autoimmune diseases such as arthritis, lupus, antiinflammatory agents, multiple sclerosis, diabetes and viral diseases | WARNER-LAMBERT CO. (US) | 1991-09-24 | — | — | US | disclosed |
| US-4952693-A | TREATING AUTOIMMUNE DISEASES | WARNER-LAMBERT COMPANY (US) | 1990-08-28 | — | — | US | disclosed |
| US-4772606-A | AUTOIMMUNE DISEASES, ORGAN TRANSPLANTS | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0178178-A2 | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1986-04-16 | — | — | EP | disclosed |