Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 6/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 6/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9798309 | 0.89 | PNP (0.62) | PNPCMA1CHRNA7XDHCYP2A6 | |
| SCHEMBL10915197 | 0.81 | PNP (0.54) | PNPDHFRCMA1XDHCYP2A6 | |
| SCHEMBL9798175 | 0.80 | PNP (0.63) | PNPHPRT1XDH | |
| SCHEMBL2128391 | 0.78 | PNP (0.76) | PNPHPRT1PDE7APDE7BDHFR | |
| SCHEMBL9799091 | 0.77 | PNP (0.50) | PNPHPRT1PDE7APDE7BDHFR | |
| SCHEMBL9798141 | 0.77 | PNP (0.78) | PNPHPRT1PDE7APDE7B | |
| SCHEMBL10507664 | 0.76 | PNP (0.51) | PNPHPRT1PDE7APDE7BDHFR | |
| SCHEMBL10506664 | 0.72 | PNP (0.60) | PNPHPRT1XDH | |
| SCHEMBL10386634 | 0.72 | PNP (0.78) | PNPHPRT1PDE7APDE7BSMN1; SMN2 | |
| SCHEMBL10506494 | 0.71 | PNP (0.58) | PNPHPRT1DHFRXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772606-A | AUTOIMMUNE DISEASES, ORGAN TRANSPLANTS | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | claimed |
| EP-0178178-A2 | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1986-04-16 | — | — | EP | claimed |
| US-5051429-A | For treatment of autoimmune diseases such as arthritis, lupus, antiinflammatory agents, multiple sclerosis, diabetes and viral diseases | WARNER-LAMBERT CO. (US) | 1991-09-24 | — | — | US | disclosed |
| US-4952693-A | TREATING AUTOIMMUNE DISEASES | WARNER-LAMBERT COMPANY (US) | 1990-08-28 | — | — | US | disclosed |
| US-4772606-A | AUTOIMMUNE DISEASES, ORGAN TRANSPLANTS | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0178178-A2 | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1986-04-16 | — | — | EP | disclosed |