Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pefloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 8/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.88 |
| ▸ | HPGD | P15428 | 3/20 | 0.88 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.77 |
| ▸ | RAD52 | P43351 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | BRD4 | O60885 | 1/20 | 0.77 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pefloxacin SCHEMBL28251251 | 0.99 | DRD3 (1.00) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL34292 | 0.99 | DRD3 (1.00) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL29351730 | 0.99 | DRD3 (1.00) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL10911017 | 0.98 | DRD3 (0.98) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL7861481 | 0.98 | DRD3 (0.98) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL9788090 | 0.98 | DRD3 (0.98) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL8184732 | 0.98 | DRD3 (0.98) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL28542234 | 0.98 | DRD3 (0.98) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL29594648 | 0.94 | KDM4E (1.00) | DRD3MEN1KMT2AKDM4EALDH1A1 | |
| Pefloxacin SCHEMBL135085 | 0.94 | KDM4E (1.00) | DRD3MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563485-A | SURGICAL IMPLANTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1986-01-07 | — | — | US | claimed |
| EP-0207624-B1 | METHOD FOR PREPARING INFECTION-RESISTANT MATERIALS | The Trustees of Columbia University in the City of New York (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0207624-A2 | Method for preparing infection-resistant materials | The Trustees of Columbia University in the City of New York (US) | 1987-01-07 | — | — | EP | disclosed |
| US-4612337-A | SOAKING POLYMERIC MATERIAL WITH MICROBIOCIDE AND SOLVENT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1986-09-16 | — | — | US | disclosed |
| US-4563485-A | SURGICAL IMPLANTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1986-01-07 | — | — | US | disclosed |
| US-4563485-A | SURGICAL IMPLANTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1986-01-07 | — | — | US | disclosed |