SCHEMBL9800583

SCHEMBL9800583

[CH2]C(C)(C)SCc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.59
CYP1A2 P05177 1/20 0.59
CYP3A4 P08684 1/20 0.59
PRMT1 Q99873 1/20 0.59
SLC6A2 P23975 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
IDO1 P14902 3/20 0.39
LMNA P02545 1/20 0.39
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
NOS2 P35228 1/20 0.39
TP53 P04637 1/20 0.39
POLB P06746 1/20 0.38
HSD17B10 Q99714 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAOB P27338 1/20 0.37
CTSL P07711 1/20 0.36
CTSB P07858 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5680420 0.81 CYP2D6 (0.63) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL4092393 0.77 CYP1A2 (0.53) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL12879664 0.76 CYP2D6 (0.68) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL7561243 0.76 CYP1A2 (0.57) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
Bromide SCHEMBL20854775 0.76 CYP1A2 (0.57) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL1654642 0.74 CYP1A2 (1.00) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL10920937 0.74 CYP2D6 (0.55) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL11188983 0.74 CYP2D6 (0.66) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL10136448 0.74 CYP2D6 (0.55) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2
SCHEMBL9068194 0.74 CYP3A4 (0.50) CYP2D6CYP1A2CYP3A4PRMT1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0416373-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1991-03-13 EP disclosed