Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800895 | 1.00 | LCK (0.61) | LCKEPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL9800929 | 0.93 | LCK (0.55) | LCKEPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL9800924 | 0.93 | LCK (0.55) | LCKEPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL17672416 | 0.85 | EPHX1 (0.57) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL9800906 | 0.84 | EPHX1 (0.57) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL9800907 | 0.84 | EPHX1 (0.57) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL10363618 | 0.83 | EPHX1 (0.58) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL10362737 | 0.83 | EPHX1 (0.58) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL9800913 | 0.83 | EPHX2 (0.55) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL9800925 | 0.83 | EPHX1 (0.55) | EPHX2EPHX1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | claimed |
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0297610-A1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1989-01-04 | — | — | EP | disclosed |