Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.58 |
| ▸ | ADA | P00813 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.52 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.52 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9479018 | 1.00 | HDAC3 (0.58) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9479659 | 0.90 | HDAC3 (0.57) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9479598 | 0.90 | HDAC3 (0.59) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9478816 | 0.88 | ADA (0.59) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9806732 | 0.87 | ADA (0.58) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9481922 | 0.86 | HDAC3 (0.55) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9479152 | 0.86 | HDAC3 (0.55) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9478206 | 0.82 | HDAC3 (0.51) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9478469 | 0.81 | HDAC3 (0.52) | HDAC3HDAC1HDAC6ADANPC1 | |
| SCHEMBL9806740 | 0.81 | ADA (0.49) | HDAC3HDAC1HDAC6ADANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |