Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.64 |
| ▸ | HRH2 | P25021 | 5/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | FAAH | O00519 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9809319 | 0.95 | HRH1 (0.69) | HRH1HRH2CYP3A4FAAHCYP2D6 | |
| Hydrochloric Acid SCHEMBL9809309 | 0.94 | HRH1 (0.68) | HRH1HRH2CYP3A4FAAHCYP2D6 | |
| SCHEMBL9809292 | 0.88 | HRH2 (0.64) | HRH1HRH2CYP3A4FAAHCYP2D6 | |
| SCHEMBL9809270 | 0.84 | HRH2 (0.69) | HRH1HRH2MEN1KMT2ADRD2 | |
| SCHEMBL9809310 | 0.83 | HRH1 (0.69) | HRH1HRH2CYP3A4FAAHCYP2D6 | |
| SCHEMBL9809265 | 0.83 | HRH1 (0.63) | HRH1HRH2MEN1KMT2AHTR2A | |
| SCHEMBL9809311 | 0.83 | HRH2 (0.63) | HRH1HRH2CYP3A4FAAHCYP2D6 | |
| SCHEMBL9809351 | 0.83 | HRH2 (0.69) | HRH1HRH2MEN1KMT2AHTR2A | |
| SCHEMBL9809323 | 0.83 | HRH1 (0.56) | HRH1HRH2CYP3A4FAAHCYP2D6 | |
| Hydrochloric Acid SCHEMBL9809260 | 0.82 | HRH2 (0.67) | HRH1HRH2CYP3A4FAAHCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0211928-B1 | PIPERAZINECARBOXAMIDES HAVING A PHENOXYALKYL OR THIOPHENOXYALKYL SIDE CHAIN | AB LEO (SE) | 1991-05-02 | — | — | EP | disclosed |