Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9776700 | 0.93 | SLC2A1 (0.83) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| Hydrochloric Acid SCHEMBL9776677 | 0.91 | SLC2A1 (0.86) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| Hydrochloric Acid SCHEMBL9776828 | 0.89 | SLC2A1 (0.82) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| Hydrochloric Acid SCHEMBL9776944 | 0.87 | SLC2A1 (0.70) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| SCHEMBL9776696 | 0.86 | SLC2A1 (0.73) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| SCHEMBL9776774 | 0.86 | SLC2A1 (0.86) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| SCHEMBL9776834 | 0.86 | SLC2A1 (0.97) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| SCHEMBL9776763 | 0.85 | SLC2A1 (0.68) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| Hydrochloric Acid SCHEMBL9776848 | 0.84 | SLC2A1 (1.00) | SLC2A1LMNASMN1; SMN2NPC1PKM | |
| Hydrochloric Acid SCHEMBL9776682 | 0.84 | SLC2A1 (0.89) | SLC2A1LMNASMN1; SMN2NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322133-B1 | QUINAZOLINE DERIVATIVES | SmithKline Beecham Intercredit B.V. (NL) | 1991-05-22 | — | — | EP | disclosed |
| WO-1989005297-A1 | COMPOUNDS | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1989-06-15 | — | — | WO | disclosed |